
Latest Version
MedCalc 23.0.2 LATEST

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Windows 7 / Windows 8 / Windows 10 / Windows 11

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Filename
medcalcsetup.msi
Originally released to the public in 1993 as a DOSonly app, MedCalc received constant upgrades, eventually moving to the Windowsonly space a few years later. As of today, this MedCalc represents one of the most popular biomedical research tools for statistical analysis of large datasets, curve analysis, data plotting, Bablok, and Deming regression, and more. The app has support for over 100 thousand spreadsheet rows, tools for sorting, filtering, and editing, and a builtin browser for managing all the data captured in the research studies. Tools for managing diagrams are available with a single click and include comparisons, scatter plots, subgroup graphs, support for up to 24 continuous variables, and much more).
The app also features advanced ROC curve analysis capabilities, enabling the creation of a ROC curve graph with 95% confidence bounds and added information of specificity, sensitivity, predictive values, likelihood ratios, conclusive plots, and more. To be more useful in larger studies, the tool can compare six ROC curves in various ways. Researchers have also praised its capability to handle missing data, calculate percentile ranks, power transformations, subgroup management, outlier detection, regression tools, and more.
Because of its complexity and wide range of usage scenarios, this app is best suited to students and researchers who have knowledge in statistics and analysis of biomedical data.
In addition to four distinct premium licenses (Lifetime singleuser, Singleuser subscription, Site license, and Network license), the software can also be tested in an unrestricted way during a free 15day trial demo.
Installation and Use
MedCalc is distributed online as a small installation package that weighs less than 30 MBs. Additionally, developers of the tool have also created a standalone free app file viewer that can be used to open .mc1 files without the need for a full MedCalc license. While Med Calc has the capability to fully modify and extract new graph insights from .md1 databases, a free viewer app can only be used to view previously set graphs and analyses.
Features and Highlights
 Powerful statistical software package for biomedical researchers.
 Fast, reliable, and userfriendly.
 Wellsuited for use in the education and medical environment.
 Builtin support for over 220 statistical tests, procedures, and graphs.
 Spreadsheet support for over 100 thousand rows of data.
 Import tools for all popular spreadsheet file formats.
 Optimized for all modern versions of Windows OS.
 One edition includes all features.
 Modest system requirements.
 Offered for sale in four premium licensing options.
 Available for FREE via a 15day trial demo.
What's new in this version:
MedCalc 23.0.2
 Fixed a font problem in graphs (in nonWestern Windows versions)
 Fixed a problem in the calculation of Harrell's C (Cox regression)
 Added the possibility to drag and drop a data file into the MedCalc window
 Fixed layout problems when text size is increased in Windows control panel  Accessibility
 Dialog boxes in the Tests menu: made the "Comments" input fields optional
 Improved several userinterface elements
 Some improvements for dark mode
 Minor bug fixes
MedCalc 23.0.1
 Added the possibility to drag and drop a data file into the MedCalc window
 Dialog boxes in the Tests menu: made the "Comments" input fields optional
 Improved several userinterface elements
 Some improvements for dark mode
Fixed:
 Fixed a font problem in graphs (in nonWestern Windows versions)
 Fixed a problem in the calculation of Harrell's C (Cox regression)
 Fixed layout problems when text size is increased in Windows control panel  Accessibility
 Minor bug fixes.
MedCalc 23
 Fixed a problem in the calculation of Harrell's C (Cox regression)
 Added the possibility to drag and drop a data file into the MedCalc window
 Fixed layout problems when text size is increased in Windows control panel  Accessibility
 Dialog boxes in the Tests menu: made the "Comments" input fields optional
 Improved several userinterface elements
 Some improvements for dark mode
 Minor bug fixes
MedCalc 22.032
 Fixed some problems in translated menus and dialog boxes
 Improvements for Dark mode
 Some bug fixes
MedCalc 22.030
 Support for Dark mode
 Fixed a problem that could hinder the use of nonlatin characters in file names
 Some bug fixes
MedCalc 22.029
 Support for Dark mode
 Fixed a problem that could hinder the use of nonlatin characters in file names
MedCalc 22.026
 Added InterItem and ItemTotal correlation in Cronbach's alpha
 Added the confidence intervals for the regression coefficients in multiple regression
 Fixed a bug that could hide the standard error of the constant in multiple regression
 MedCalc now allows the Xaxis of a histogram to be changed after it has been created
 In Variable properties, added the possibility to mark a variable as categorical and select a reference category (such as used in Logistic regression and Cox proportionalhazards regression)
 Some bug fixes
MedCalc 22.023
 An improvement of the display of subscript/superscript of text in graphs
 Revised dialog boxes  usually resulting in larger text (depending on your screen resolution)
 Fixed a bug in scripts where the system variable $PlotAllPoints was not always processed correctly
 Revised layout of script window
 Fixed a problem in the 32bits MedCalc version which caused "unknown command" errors in scripts
New script commands and functions:
 SaveGraph(filename, graphid) saves a graph on disk
 FileList([path,][mask]) lists files into a table
 GetOpenFilename([path,][mask]) displays a dialog in which the user can select a file for reading; the function returns the selected file.
 GetSaveFilename([path,][mask]) displays a dialog in which the user can select a file for writing; the function returns the selected file.
 SelectFolder() displays a dialog in which the user can select a disk folder; the function returns the selected folder.
New string function:
 FIND(needle,haystack[,startpos]) returns the position of a specific text within another text
 LTRIM(str) removes leading spaces from text
 TRIM(str) removes all spaces from text except for single spaces between words
 RTRIM(str) removes trailing spaces from text
MedCalc 22.021
 Fixed a problem in the legend for scatter diagram in case a trendline and subgroups were selected
 Some minor bugs fixes
MedCalc 22.020
 Fixed some minor bugs
MedCalc 22.019
 Added an option for a secondary Yaxis in Histograms
 Fixed some minor bugs
MedCalc 22.018
 Fixed a bug in the display of the result of the D'AgostinoPearson test for normal distribution Create summary statistics table
MedCalc 22.017
 Change log not available for this version
MedCalc 22.016
 New: Waterfall charts
MedCalc 22.014
 Fixed some minor display problems
MedCalc 22.013
 New: Comparison of trimmed means of paired samples
 New: YuenWelch test for the comparison of 2 independent trimmed means
Computional notes are given on Calculation of Trimmed Mean, SE and confidence interval
Revision of the definition of "percentage trimmed":
 In previous MedCalc versions, for a 20% trimming, the program would trim 10% at the lower tail and 10% at the higher tail, so 20% in total. This was in agreement with Excel
 In the new MedCalc version, for a 20% trimming, the program trims 20% at the lower tail and 20% at the higher tail, so 40% in total. This is in agreement with SPSS, R and other major statistical packages.
 For the summary statistics report, when recalling older analyses, MedCalc will adapt the % value of the trimmed mean. When you selected a 20% trimmed mean in the old version, the report will show that this is now called a 10% trimmed mean. The reported trimmed mean will remain the same. For new analyses, the new definition will be applied automatically.
 For the trimmed mean spreadsheet functions there will be no conversion and the calculated trimmed mean will always be that corresponding to the revised definition. The calculated trimmed mean will be different.
 Fixed a bug that could cause the program to produce an error when using MedCalc Help in the Help menu
MedCalc 22.012
 New: Comparison of trimmed means of paired samples
 New: YuenWelch test for the comparison of 2 independent trimmed means
Computional notes are given on Calculation of Trimmed Mean, SE and confidence interval
Revision of the definition of "percentage trimmed":
 In previous MedCalc versions, for a 20% trimming, the program would trim 10% at the lower tail and 10% at the higher tail, so 20% in total. This was in agreement with Excel
 In the new MedCalc version, for a 20% trimming, the program trims 20% at the lower tail and 20% at the higher tail, so 40% in total. This is in agreement with SPSS, R and other major statistical packages.
 For the summary statistics report, when recalling older analyses, MedCalc will adapt the % value of the trimmed mean. When you selected a 20% trimmed mean in the old version, the report will show that this is now called a 10% trimmed mean. The reported trimmed mean will remain the same. For new analyses, the new definition will be applied automatically.
 For the trimmed mean spreadsheet functions there will be no conversion and the calculated trimmed mean will always be that corresponding to the revised definition. The calculated trimmed mean will be different.
MedCalc 22.009
 Change log not available for this version
MedCalc 22.007
 Fixed a bug that caused text not to be displayed correctly in graph text boxes
MedCalc 22.005
 Change log not available for this version
MedCalc 22.004
 Fixed bugs in MedCalc scripts (ForEach and Proc statements)
MedCalc 22.001
 Version 22 introduces a new file format. The new format is faster and lighter. Important: files saved in MedCalc version 22 cannot be read by previous MedCalc versions. Files saved in all previous MedCalc versions can be read by this version; but when saved, the new file format is used.
 New: Scripts
 New spreadsheet functions EVAL, FREQUENCY, VFREQUENCY, DEVSQ, VDEVSQ, INTERCEPT, VINTERCEPT, STEYX, VSTEYX, TESTNORM and VTESTNORM.
 Redefined the CELL function.
 Fixed a bug in Case control matching when saving the matched data to a new file.
 In Diagnostic test (2x2 table): when predictive value is 0 or 100%, a ClopperPearson confidence interval is reported.
 New operators ! (Not), && (And),  (Or)
 The operator != can be used as an alternative to the <> (Not equal) comparison operator. E.g. 5!=1 is true.
MedCalc 20.305
 Fixed a bug in Case control matching when saving the matched data to a new file
 In Diagnostic test (2x2 table): when the predictive value is 0 or 100%, a ClopperPearson confidence interval is reported
MedCalc 20.218
 Fixed a problem with the display of the Diagnostic test dialog box
MedCalc 20.217
 In Frequency tables (Chisquared test) and Fisher's exact test, moved the option to show all percentages from the results window to the dialog box. This fixes a problem with copyingpasting results to other programs
 Fixed a bug in the Categorize function, which could cause the function to always return the default value
 Fixed a problem with multiple monitors
MedCalc 20.216
Fixed:
 In Frequency tables (Chisquared test) and Fisher's exact test, moved the option to show all percentages from the results window to the dialog box. This fixes a problem with copyingpasting results to other programs.
 Fixed a bug in the Categorize function, which could cause the function to always return the default value
 Fixed a problem with multiple monitors
MedCalc 20.214
 In Frequency tables (Chisquared test) and Fisher's exact test, moved the option to show all percentages from the results window to the dialog box. This fixes a problem with copyingpasting results to other programs.
 Fixed a bug in the Categorize function, which could cause the function to always return the default value
 Fixed a problem with multiple monitors
MedCalc 20.211
 Some improvements for high resolution screens and minor userinterface changes
MedCalc 20.2
 Added several new options for Correlogram and Correlation table
 Changed the methodology of the calculation of the Pvalue in the MannWhitney test, the Signed rank sum test and paired samples Wilcoxon test. In these tests, when an exact Pvalue can be calculated, the program will also report the Normal approximation method Pvalue in a footnote below the table.
 Changed some more visual aspects of windows and dialog boxes (mainly corrections of low contrast issues in Windows 11)
 Corrected a problem that caused the file selector box to remain hidden behind the MedCalc main window when printing to a file or PDF
 Corrected a problem that could fail a logical expression when data were missing.
MedCalc 20.123
 Changed the methodology of the calculation of the exact Pvalue in the MannWhitney test. The new algorithm is based on the U statistic. Exact Pvalues are reported when both sample sizes are ≤25 and there are no ties.
 In Correlation tables added an option to hide the upperright triangular part
MedCalc 20.121
Frequencies bar chart: provided options:
 to enter the counts
 to sort the bars by magnitude
 for horizontal display
 MannWhitney test: use the large sample statistic when either size is larger than 15 (previously 20)
MedCalc 20.118
 Improved integration with Windows 11
MedCalc 20.116
 Import of Excel *.xls files: changed the handling of text cells (removed the leading apostrophe that was added in previous MedCalc versions).
MedCalc 20.115
Fixed:
 Fixed a bug in PassingBablok regression that caused the scatter diagram not to show the regression line when Bootstrapping was enabled.
 Fixed a bug that could cause errors in the posthoc test of the Friedman test.
MedCalc 20.114
 Fixed a bug in PassingBablok regression that caused the scatter diagram not to show the regression line when Bootstrapping was enabled
MedCalc 20.113
 Fixed a bug in Outlier detection when the ShapiroFrancia normality test was used. In that case the linked values did not always redirect to the correct cases in the spreadsheet.
MedCalc 20.112
 Fixed a bug that could cause, in some cases, the use of wrong markers for subgroups in scatter diagrams
MedCalc 20.110
 Fixed a bug in the display of the selected significance level for the posthoc tests in Anova and KruskallWallis test
MedCalc 20.109
 Fixed a bug in the normality test for residuals in several tests (the results of the KolmogorovSmirnov test were not displayed)
 Several other bug fixes and improvements
MedCalc 20.106
 Change log not available for this version
MedCalc 20.105
 Change log not available for this version
MedCalc 20.104
 Corrected a problem in the calculation of Nagelkerke's R2 in Logistic and Probit regression, in case of a large null model −2 Log Likelihood
 Corrected a problem that caused failure of saving very large Excel files (*.xlsx)
 When bootstrapping takes a long time, a dialog box is displayed with the estimated time left, and a button to interrupt the procedure
 New: scientific, mathematical and system Constants
 New functions: Random, Pow10, CountIf, SumIf, BOXCOX BoxCox transformation, and BOXCOXINV inverse of the BoxCox transformation
 Improved speed of several statistical procedures
MedCalc 20.100
 Corrected a problem in the calculation of Nagelkerke's R2 in Logistic and Probit regression, in case of a large null model −2 Log Likelihood
 Corrected a problem that caused failure of saving very large Excel files (*.xlsx)
 When bootstrapping takes a long time, a dialog box is displayed with the estimated time left, and a button to interrupt the procedure
 New: scientific, mathematical and system Constants
 New functions: Random, Pow10, CountIf, SumIf, BOXCOX BoxCox transformation, and BOXCOXINV inverse of the BoxCox transformation
 Improved speed of several statistical procedures
MedCalc 20.027
 Fixed a problem that caused the program to block when ROC curve analyis was used in very large sample
MedCalc 20.026
 Fixed a bug that caused the Wilcoxon Signed Rank test not to calculate a small sample size test statistic in some circumstances
MedCalc 20.023
 Fixed a bug in the Undo function of the spreadsheet
 Reversed the order of the arguments in the spreadsheet functions CELL and CELLVALUE
MedCalc 20.022
 Added an option to create a backup copy (*.mc1.bak.zip) when you save a *.mc1 file. See Save options.
 Some userinterface and performance improvements
MedCalc 20.019
 In Reports added a button to extract an analysis or graph into a separate window
 Added an option to increase the number of decimal places used in reports, see Reports options
 The dialog boxes for the calculators in the Tests menu and Sample size menu are now nonmodal. This means that you can have several calculators open at the same time, without preventing access to the rest of the program.
 Improved algorithm for identifying data points in graphs
MedCalc 20.018
 In Reports added a button to extract an analysis or graph into a separate window
 Added an option to increase the number of decimal places used in reports, see Reports options
 The dialog boxes for the calculators in the Tests menu and Sample size menu are now nonmodal. This means that you can have several calculators open at the same time, without preventing access to the rest of the program.
 Improved algorithm for identifying data points in graphs.
MedCalc 20.015
 Added an option to slightly shift ("jitter") coincident data points in scatter diagrams so that the markers do not completely overlap. See Applying jitter in scatter diagrams.
 Several other minor improvements.
MedCalc 20.014
 Several minor bug fixes and improvements.
MedCalc 20.013
 Fixed a bug in Logistic regression which caused the regression curve not to be displayed in the graph.
MedCalc 20.010
 Modified report for Cox proportionalhazards regression includes Harrell's Cindex with 95% confidence interval.
 Revised layout of Copy graph options and Export graph options
 In Copy graph options, provided an option Also copy in SVG format. Copying graphs in SVG format is recommended when you are using Office 2016 (when all Office updates are installed), Office 2019 or Office 365.
 Added the confidence interval of the difference in Comparison of correlation coefficients.
 Fixed a bug in the calulation of the specificity corresponding to the Youden index in ROC curve analysis.
 Fixed a problem in formatting the legend in BlandAltman plots.
MedCalc 20.006
 The BlandAltman plot and BlandAltman plot with multiple measurements per subject procedures now also generate a report in addition to the graph.
MedCalc 20.0.5
 Added Partial area under ROC curve and Comparison of partial areas under ROC curves
 In Comparison of PrecisionRecall curves added a choice between paires samples or independent samples design.
MedCalc 20
 Added transparency option for drawing objects (text box, rectangle, ellipse).
 Added a shaded area option for the confidence interval of a KaplanMeier survival curve, ROC curve, Linear regression, Probit regression, PassingPablok regression and BlandAltman plots (rightclick on the confidence interval curve and select a fill color in the "Format..." dialog box).
 Added Sample size calculation for Area Under the PrecisionRecall curve.
 Changed the method of calculating the confidence interval for the AUC of precisonrecall curves to the Logit method of Boyd et al (2013). The bootstrap method remains available for calculating the confidence interval for the difference of AUCs of two precisonrecall curves.
 Added a Subgroups option in Comparison of multiple methods.
 Possibility to enter userdefined values that indicate missing values (e.g. NaN, 99999). This can be found in File menu > Properties > Missing values tab.
 Color option for missing values (Options panel).
 New spreadsheet functions USRMISSING() and ISMISSING().
 Moved option Enter key moves cell pointer to the Edit menu.
 Expanded color palette for graphs; includes selected colorblind safe colors (Wong, 2011).
 New color selectors.
 Added icons for common menu items.
 Some bug fixes and minor improvements.
 Files created or saved witMedCalc 20 of MedCalc will not be readible by older versions of the software (no backward compatibility). If you exchange a MedCalc file with a colleague who has an older version, he/she can always freely download the most recenMedCalc of MedCalc from our website.
MedCalc 19.8
 Moved the Export graph options (image width & height, DPI) to the Options panel in the Tools menu.
 Added the (exact midP double sided) Pvalue for incidence rate ratio.
 Fixed a problem with the display of numbers (in some cases) when using a digit grouping symbol.
 Provided an option to make all the markers the same across all individuals in BlandAltman plot with multiple measurements per subject.
MedCalc 19.7.4
 Added an option in Comparison of multiple methods to calculate differences as variable − reference or reference − variable.
 Some improvements for high resolution screens.
MedCalc 19.7
 Added Violin plots.
MedCalc 19.6.4
 Several bug fixes, minor changes, and improvements.
MedCalc 19.5.3
 Added Egger's and Begg's tests for publication bias in metaanalysis.
MedCalc 19.5
Added:
 Precisionrecall curve
 Comparison of precisionrecall curves
Added support for SVG files (an image file format):
 SVG stands for Scalable Vector Graphics
 SVG images can be edited with Adobe Illustrator, CorelDRAW, Inkscape (Free!), and other popular vector drawing programs (and even with a text editor)
 SVG images are scalable
 SVG images can be printed with high quality at any resolution
 SVG graphics do NOT lose any quality if they are zoomed or resized
MedCalc 19.4
 Added Cochran–Mantel–Haenszel test.
 Added the Cstatistic (which is the area under the ROC curve) in Cox proportionalhazards regression.
 Added an option to create a Heat map in scatter diagrams.
 Minor change in the drawing of CI bars in KaplanMeier survival curves.
 Corrected a problem in the evaluation of the OR() function.
 Corrected a problem in copying/pasting results from dialog panels.
MedCalc 19.3
 New reports feature allows to compile several analyses into one single report.
 Completely revised Help (F1) function: when your computer is connected to the internet (and can reach https://www.medcalc.org) the help function shows the same complete documentation as the manual on the website.
 Support for Windows XP has been dropped.
MedCalc 19.2.5
 New spreadsheet function AGGREGATE.
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